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A synthetic hexapeptide growth hormone secretagogue that acts as a ghrelin receptor (GHS-R1a) agonist. Studies have investigated its potent stimulation of growth hormone release from the anterior pituitary.
GHRP-2 (Growth Hormone Releasing Peptide 2, pralmorelin) is a synthetic hexapeptide that binds to the growth hormone secretagogue receptor type 1a (GHS-R1a), the same receptor targeted by endogenous ghrelin. Activation of this receptor on pituitary somatotrophs stimulates GH release through a pathway distinct from and complementary to GHRH signaling. GHRP-2 also suppresses somatostatin release, removing inhibitory tone on GH secretion. Among the GHRP family, GHRP-2 is considered one of the most potent GH secretagogues, with moderate effects on cortisol, ACTH, and prolactin compared to GHRP-6.
Bowers CY, et al. On the in vitro and in vivo activity of a new synthetic hexapeptide that acts on the pituitary to specifically release growth hormone. Endocrinology. 1984;114(5):1537-1545.
Key finding: Established the foundational evidence for synthetic GH-releasing peptides, demonstrating potent and specific GH release from pituitary cells.
Ishida J, et al. Growth hormone secretagogues: history, mechanism of action, and clinical development. JCSM Rapid Communications. 2020;3(1):25-37.
Key finding: Comprehensive review establishing GHRP-2 as among the most potent synthetic GH secretagogues with demonstrated utility in GH stimulation testing research.
| Type | Peptide (hexapeptide) |
Research Use Only (RUO): This page summarizes published scientific research and is provided for educational and informational purposes only. It is not intended as medical advice, diagnosis, or treatment recommendations. The compound described carries a Research Use Only designation and is intended for laboratory research use only. It is not intended for human or animal consumption, or for use in the diagnosis, treatment, cure, or prevention of any disease. Consult qualified professionals before making any health-related decisions.